Access channel residues Ser315 and Asp137 in Mycobacterium tuberculosis catalase-peroxidase (KatG) control peroxidatic activation of the pro-drug isoniazid.
نویسندگان
چکیده
Peroxidatic activation of the anti-tuberculosis pro-drug isoniazid by Mycobacterium tuberculosis catalase-peroxidase (KatG) is regulated by gating residues of a heme access channel. The steric restriction at the bottleneck of this channel is alleviated by replacement of residue Asp137 with Ser, according to crystallographic and kinetic studies.
منابع مشابه
Isonicotinic acid hydrazide conversion to Isonicotinyl-NAD by catalase-peroxidases.
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ورودعنوان ژورنال:
- Chemical communications
دوره 49 99 شماره
صفحات -
تاریخ انتشار 2013